Tadalafil 20mg is also called 36-hour Cialis. It works in as little as 30 minutes and can also work for up to 36 hours.
ecreases, and your erection will go away.
With Tadalafil 20mg you don’t have to plan around meals because the absorption of tadalafil is nexual activity is over, blood flow to the penis dot affected by food. That means you can eat and drink what you want. But it is not recommended to drink alcohol when taking tadalafil 20mg. Too much alcohol can increase your chances of:
• A drop in blood pressure
• Increased heart rate
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Tadalafil - A Drug Used for Male Erictile Dysfunction .
Tadalafil is an orally administered drug used to treat male erectile dysfunction (impotence). It was initially developed by the biotechnology firm ICOS and subsequently developed and marketed worldwide by a joint venture of ICOS Corporation and Eli Lilly and Company (Lilly ICOS LLC) under the brand name Cialis. In the United States, tadalafil has Food and Drug Administration approval and became available in December, 2003 as the third impotence pill after sildenafil (Viagra) and vardenafil (Levitra). Due to its 36-hour effect it is also known as the weekend pill. As with sildenafil and vardenafil, it is recommended that tadalafil be used no more than once daily.
Although Viagra, Levitra, and Cialis all work by inhibition of phosphodiesterase type 5 (PDE5), tadalafil's distinguishing pharmacologic feature is its longer half-life (17.5 hours) compared with Viagra and Levitra (4-5 hours). This longer half-life results in a longer duration of action and is, in part, responsible for the Cialis nickname of the "weekend pill." This longer half-life also is the basis of current investigation for tadalafil's use in pulmonary arterial hypertension as a once-daily therapy.
Penile erection during sexual stimulation is caused by increased penile blood flow resulting from the relaxation of penile arteries and corpus cavernosal smooth muscle. This response is mediated by the release of nitric oxide (NO) from nerve terminals and endothelial cells, which stimulates the synthesis of cGMP in smooth muscle cells. Cyclic GMP causes smooth muscle relaxation and increased blood flow into the corpus cavernosum. The inhibition of phosphodiesterase type 5 (PDE5) enhances erectile function by increasing the amount of cGMP. Tadalafil (as well as sildenafil and vardenafil) inhibits PDE5. Because sexual stimulation is required to initiate the local release of nitric oxide, the inhibition of PDE5 by C22 H19 N3 O4 tadalafil has no effect in the absence of sexual stimulation. The recommended starting dose of Cialis in most patients is 10 mg, taken as needed before anticipated sexual activity (but no more than once daily). The dose may be increased to 20 mg or decreased to 5 mg, based on individual efficacy and tolerability. To avoid the inconvience of men with erectile dysfunction needing to plan use of Cialis around anticipated sexual activity, Lilly ICOS embarked upon a clinical development program to evaluate the benefits and risks of chronic (once-a-day) use. In June 2007, the European Commission approved low-dose (2.5 mg and 5 mg) Cialis to be used as a once-a-day therapy for men with erectile dysfunction.
A Brief History Lesson about Tadalafil (Cialis)
Tadalafil is a PDE5 inhibitor. It is most often known by the name of Cialis. It is used to treat erectile dysfunction.
This medication has also been approved for the treatment of pulmonary arterial hypertension. It also has been used for other conditions, which are not necessarily officially FDA approved.
One of the biggest concerns of course is using tadalafil or any brand name equivalent of this drug as a recreational drug. This is largely frown upon because it could cause danger especially if large amounts of it are mixed with alcohol or other substances such as the following: street drugs, over-the-counter medications, marijuana (even if prescribed medically), or prescription medications (including other ED meds).